Understanding the mechanisms of mechanical unloading to achieve myocardial recovery
نویسندگان
چکیده
منابع مشابه
Mechanical unloading promotes myocardial energy recovery in human heart failure.
BACKGROUND Impaired bioenergetics is a prominent feature of the failing heart, but the underlying metabolic perturbations are poorly understood. METHODS AND RESULTS We compared metabolomic, gene transcript, and protein data from 6 paired samples of failing human left ventricular tissue obtained during left ventricular assist device insertion (heart failure samples) and at heart transplant (po...
متن کاملMyocardial recovery by mechanical unloading with left ventricular assist system.
It has been generally believed that advanced congestive heart failure (HF) is progressive, but there is increasing evidence that mechanical unloading with the use of left ventricular assist system (LVAS) occasionally reverses the progress of HF and permits device explantation. This "bridge to recovery" strategy is attracting interest, not only for the treatment of severe HF, but also in the stu...
متن کاملDoes the beta2-agonist clenbuterol help to maintain myocardial potential to recover during mechanical unloading?
OBJECTIVE Chronic mechanical unloading induces left ventricular (LV) atrophy, which may impair functional recovery during support with an LV-assist device. Clenbuterol, a beta2-adrenergic receptor (AR) agonist, is known to induce myocardial hypertrophy and might prevent LV atrophy during LV unloading. Furthermore, beta2-AR stimulation is reported to improve Ca2+ handling and contribute to antia...
متن کاملUnderstanding the mechanisms of lung mechanical stress.
Physical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These forces include changes in stress (force pe...
متن کاملDoes the 2-Agonist Clenbuterol Help to Maintain Myocardial Potential to Recover During Mechanical Unloading?
Objective—Chronic mechanical unloading induces left ventricular (LV) atrophy, which may impair functional recovery during support with an LV-assist device. Clenbuterol, a 2-adrenergic receptor (AR) agonist, is known to induce myocardial hypertrophy and might prevent LV atrophy during LV unloading. Furthermore, 2-AR stimulation is reported to improve Ca handling and contribute to antiapoptosis. ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2018
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00586.2018